The Calciferol receptor (VDR) is a nuclear transcriptional regulator of multiple genes. It is pleiotropic results on multiple physiological devices make it a desired target designed for investigating disease mechanisms and therapeutic responses. Within an in-vitro assay, the FokI CC genotype of VDR showed an improved response to 1, 25-dihydroxyvitamin D 3 (VitD3) in comparison with the TT genotype. The in response can be due to the gear expression of varied enzymes involved with hydroxylase activity and the formation of 25-dihydroxyvitamin D3 inside the two genotypes.
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